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Regarding the expression of core defense molecules, multiple independent research teams have consistently reported significantly downregulated GPX4 protein and mRNA levels in OA patient cartilage tissues, or in vitro chondrocytes treated with inflammatory cytokines like interleukin-1β(IL-1β) to mimic the OA inflammatory environment, or under direct iron overload conditions

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[DOI] [PubMed] [Google Scholar] 152.Shu D.Y., Wojciechowski M., Lovicu F.J